KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK1
All Species:
46.97
Human Site:
S212
Identified Species:
73.81
UniProt:
O14757
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14757
NP_001107593.1
476
54420
S212
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
Chimpanzee
Pan troglodytes
XP_001145968
476
54387
S212
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
Rhesus Macaque
Macaca mulatta
XP_001111357
476
54432
S212
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
Dog
Lupus familis
XP_852191
460
52810
S196
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
Cat
Felis silvestris
Mouse
Mus musculus
O35280
476
54363
S212
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
Rat
Rattus norvegicus
Q91ZN7
476
54410
S212
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513209
476
53924
S212
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
C
Chicken
Gallus gallus
Q8AYC9
476
53830
S212
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
Frog
Xenopus laevis
Q6DE87
474
53957
P211
G
E
L
P
W
D
Q
P
N
E
V
C
Q
E
Y
Zebra Danio
Brachydanio rerio
NP_956487
410
46756
S163
E
L
P
W
D
Q
P
S
E
N
C
Q
E
Y
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61661
512
57815
S224
E
L
P
W
D
Q
P
S
T
N
C
T
E
F
T
Honey Bee
Apis mellifera
XP_623436
467
53927
L210
E
L
P
W
D
Q
S
L
A
E
C
P
E
Y
M
Nematode Worm
Caenorhab. elegans
Q9N3Z3
503
56917
S232
E
L
P
W
D
R
A
S
D
A
S
Q
S
Y
M
Sea Urchin
Strong. purpuratus
NP_001091925
468
52554
T212
E
L
P
W
D
E
P
T
Y
S
C
K
E
Y
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84VQ3
439
49610
A173
G
D
G
L
L
H
T
A
C
G
T
P
N
Y
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.3
93.2
N.A.
93.2
94.3
N.A.
89.9
84.4
77.7
56.9
N.A.
46
45.5
32
57.9
Protein Similarity:
100
100
99.7
95.1
N.A.
97
97.2
N.A.
95.3
91.5
86.7
71
N.A.
62.8
63.8
48.7
73.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
0
80
N.A.
66.6
60
60
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
13.3
93.3
N.A.
86.6
60
73.3
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
7
7
7
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
7
0
80
7
0
0
14
% C
% Asp:
0
7
0
0
87
7
0
0
60
0
0
0
0
0
0
% D
% Glu:
87
7
0
0
0
7
0
0
7
14
0
0
80
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
14
0
7
0
0
0
0
0
0
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% K
% Leu:
0
87
7
7
7
0
0
7
0
0
0
0
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
14
% M
% Asn:
0
0
0
0
0
0
0
0
7
14
0
0
7
0
0
% N
% Pro:
0
0
87
7
0
0
74
7
0
0
0
14
0
0
0
% P
% Gln:
0
0
0
0
0
74
7
0
0
0
0
67
7
0
0
% Q
% Arg:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
7
74
0
60
7
0
7
0
47
% S
% Thr:
0
0
0
0
0
0
7
7
7
0
7
7
0
0
7
% T
% Val:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
87
7
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
7
0
0
0
0
87
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _